NFL Week 3 betting guide: Spotlight turns to MNF
Jerome Miron-USA TODAY Sports

NFL Week 3 betting guide: Spotlight turns to MNF

Just like that, we're full steam ahead into Week 3. The theme of this weekend's action seems to be road favorites, as the vast majority of games have a road team favored to win. Let's dive into the full slate and highlight some betting angles to consider for each NFL game this weekend.

Kansas City Chiefs @ Indianapolis Colts

Spread: Kansas City -5.5
Total: 50.5 points

The Colts have looked pitiful this season, tying the Texans and getting shutout by the Jaguars. While Michael Pittman was out for their loss to Jacksonville, it's inexcusable for this offense to not get something going last week. Meanwhile, Patrick Mahomes and the Chiefs are quietly winning, the offense hasn't lost a step. The choice is clear for us.

Betting: Chiefs -5.5

Buffalo Bills @ Miami Dolphins

Spread: Buffalo -5
Total: 52.5 points

Miami was a part of one of the most electrifying comebacks we've seen in some time, coming back from down 21 to shock the Ravens. This is a huge litmus test for this offense, as Buffalo has dominated the Rams and Titans to begin their season. News has emerged that the Bills secondary will be without some key contributors on Sunday. That makes us want to bet on some fireworks, we're taking the points.

Betting: Over 52.5 points

Philadelphia Eagles @ Washington Commanders

Spread: Philadelphia -6
Total: 47.5 points

This will be the first game that former Eagles quarterback Carson Wentz faces the team that unceremoniously dumped him on the Colts last year. That separation was anything but pleasant, and we expect Wentz to try his best at revenge. Unfortunately for him, we're banking that he tries just a bit too hard and makes his signature mistakes. Wentz has thrown three interceptions in two games, and this Eagles defense has five interceptions this year. 

Betting: Carson Wentz to throw an interception (-165 DK)

Cincinnati Bengals @ New York Jets

Spread: Cincinnati -6
Total: 45 points

What a disappointing start for the AFC champs. Cincinnati is 0-2, and both their secondary and offensive line have been a problem area to start the season. We're going to hone in on their defense for our action in this game. In Week 1, rookie receiver for the Jets, Garrett Wilson, had 52 yards. He exploded last Sunday to the tune of 102 yards and a pair of touchdowns. Cincy has allowed pass-catchers to go over their receiving totals in each game so far, we're betting it happens again.

Betting: Garrett Wilson over 50.5 receiving yards (-110 DK)

Detroit Lions @ Minnesota Vikings

Spread: Minnesota -6
Total: 52.5 points

No team has allowed more touchdowns to running backs than Detroit this year, four total through two games. This was a vulnerability and seems to have carried over into 2022. Dalvin Cook is a great bet to find the end zone, even with the odds slightly juiced.

Betting: Dalvin Cook TD (-150 MGM)

Baltimore Ravens @ New England Patriots

Spread: Baltimore -2.5
Total: 44 points

This Ravens secondary has been an issue, and while we'd bet they beat the Patriots, we prefer to target a New England passing prop to take advantage. Baltimore has allowed a touchdown to a tight end in each game this season, and this after allowing the sixth-most TDs to the position last season. It's a toss-up in New England, but given Jakobi Meyers may not play, we're looking at Hunter Henry to score this weekend.

Betting: Hunter Henry TD (+390 DK)

Las Vegas Raiders @ Tennessee Titans

Spread: Las Vegas -2
Total: 45.5 points

Did you watch Monday night as the Bills torched the Titans? Stefon Diggs continuously broke free for a big play, scoring three times. Given this vulnerability, we'd like to look Las Vegas's way, and there's no one better to bet on than Davante Adams. Adams has been targeted down the field plenty this season, and we see a big pass from Derek Carr this weekend.

Betting: Davante Adams over 24.5 long reception (-120 DK)

New Orleans Saints @ Carolina Panthers

Spread: New Orleans -2.5
Total: 41 points

This has the makings of an ugly, low-scoring game. Jameis Winston and this New Orleans offense look out of sorts and could struggle to manufacture points, while the Saints defense has been tough and should be able to stop Baker Mayfield. We're taking the under here.

Betting: Under 41 points

Houston Texans @ Chicago Bears

Spread: Chicago -3
Total: 39.5 points

Believe it or not, Houston is 2-0 ATS this season. Brandin Cooks should be able to get by this very soft Chicago secondary for a big game, and Justin Fields and this Bears passing offense has seemed anemic. Not sure why the Bears are favored, the Texans seem like the better team.

Betting: Texans +3

Jacksonville Jaguars @ Los Angeles Chargers

Spread: Los Angeles -7
Total: 47 points

We hope Justin Herbert is okay, it seems like he will be playing with a rib protector. One thing these teams have in common is that both have been susceptible to the big play. Christian Kirk has had a nice start for Jacksonville, while the Chargers pass-catching options run deep. This could be an exciting AFC game, and we're thinking both Trevor Lawrence and Herbert go back and forth all game.

Betting: Over 47 points

Los Angeles Rams @ Arizona Cardinals

Spread: Los Angeles -3.5
Total: 48.5 points

If the Cardinals didn't come back and win last week, this spread would have been bigger. There's some merit to betting the home dogs in a divisional game, but this Cardinals defense has been such a major issue. Only one team has allowed more touchdowns in two games than Arizona. While they may be able to keep up, the safest bet we see is on the Rams scoring plenty of points.

Betting: Rams over 26.5 points (-110 DK)

Green Bay Packers @ Tampa Bay Buccaneers

Spread: Tampa Bay -1
Total: 42 points

Tom Brady's options are limited in this game with the Mike Evans suspension and injuries to Chris Godwin and Julio Jones. Sure, the Bucs are 2-0 and playing at home, but this is a strong Packers defense that can give this offense fits. Both teams are 2-0 to the under thanks to their defense, and it seems like we may be in store for another tight, close contest. The total opened at 48 and quickly was bet down, so while we missed out on that line, it still feels like the right call.

Betting: Under 42 points

Atlanta Falcons @ Seattle Seahawks

Spread: Seattle -1
Total: 42 points

Atlanta has allowed five touchdowns to wide receivers this season, the most in the NFL. It was a problem area for the Falcons defense last season, and here we are and nothing has changed. Geno Smith has yet to connect on a touchdown pass to Tyler Lockett or DK Metcalf this season. The targets have been similar, but Lockett has had the bigger game thus far. It's a toss up, so we're going with the better odds on who finally scores.

Betting: Tyler Lockett TD (+210 FD)

San Francisco 49ers @ Denver Broncos

Spread: San Francisco -1.5
Total: 44.5 points

Quite the disappointing start for Russell Wilson and the Broncos thus far. Yes, they won last week, but it's hard to deem a 16-9 victory over Houston as much of a win. The 49ers are turning to Jimmy Garoppolo after the Trey Lance injury. Jimmy G and Wilson have plenty of history together in the NFC West, and in six career starts against each other, Wilson is 5-1. We're backing the Broncos to figure things out.

Betting: Broncos moneyline +100

Dallas Cowboys @ New York Giants

Spread: New York -1
Total: 39 points

We've seen better MNF contests, that's for sure. This Dallas defense is great, with Micah Parsons leading the way. Backup quarterback Cooper Rush had a good game in Week 2, but it's still hard to feel confident backing him. However, the other side has the 2-0 Giants who have beaten two bad teams, it's hard to know how to read them. This is tough, but we're just going with the home team in a divisional game.

Betting: Giants -1

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